What is broad bean disease
broad bean disease is a disease caused by the lack of glucose 6-phosphate dehydrogenase (G-6-PD), which is characterized by sudden acute intravascular hemolysis after eating fresh broad beans.
patients are mainly distributed in the provinces south of the Yangtze River, mainly in Hainan, Guangdong, Guangxi, Yunnan, Guizhou, Sichuan and other provinces. The cause of the disease is that the G6PD gene mutation leads to the decrease of the enzyme activity, and the red blood cells cannot resist oxidative damage and suffer damage, resulting in hemolytic anemia.
what are the symptoms of broad bean disease?
patients generally have acute intravascular hemolysis within 1-2 days after eating broad beans. Once it occurs, it will be fierce, manifested as general discomfort, pale face, slight heat, dizziness, fatigue and weakness, anorexia, abdominal pain, nausea, deepening urine color, etc. After that, jaundice, anemia and hemoglobinuria occurred, and the urine was oily. After that, the body temperature increased and the fatigue increased, lasting for about 3 days.
when hemolytic anemia occurs at the same time, vomiting, diarrhea and abdominal pain will increase, liver enlargement and abnormal liver function will occur, and about 50% of patients will have splenomegaly. In severe cases, it may lead to coma, shock and systemic failure. If the first aid is not timely, it often dies within 1-2 days.
what is the cause of broad bean disease?
sex chromosome recessive inheritance is the cause of broad bean disease. The so-called recessive inheritance means that when a pair of x sex chromosomes of women have disease genes, they will get sick, while men will get sick as long as the X chromosome is abnormal. Women with only one abnormal X chromosome have no symptoms, but their boys will get sick if they get the abnormal X chromosome.
broad bean disease should pay attention to
broad bean disease is serious in prevention. Broad bean disease examination is helpful to reduce the occurrence of neonatal hemolysis. In addition, parents whose children have broad beans at home should also pay attention to the following points.
1. It is forbidden to eat broad beans or processed broad beans. Pearl powder, honeysuckle, Sichuan lotus, bezoar and bear bile should also be avoided.
2. Less contact with prohibited products, such as camphor, stinky pill, Holly oil, pigment, mint paste, Ping An paste, Dieda wine, etc.
3. Avoid going to the broad bean field during the flowering, fruiting or harvest season of broad bean.
4, beware of pesticide spray. Some insecticide spray can definitely dissolve the blood, so you should pay special attention when using it.
5. It is not suitable to take oxidizing drugs, such as primaquine, sulfonamides, furans, vitamins K3, K4, phenacetin, aminopyrine, sulfones, etc.